Colorectal Cancer 2025
The Ultimate Dark-Mode Guide • Updated December 2025
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What is Colorectal Cancer?
Colorectal cancer starts in the colon or rectum. Most cases begin as polyps — small growths that can turn cancerous over 10–15 years. It is the 3rd most common cancer worldwide and the 2nd deadliest, but it is highly preventable and curable when caught early.
2025 Key Statistics (US)
- New cases: ~153,000
- Deaths: ~53,000
- Early-stage (I) 5-year survival: >90%
- Metastatic (IV) 5-year survival: ~15%
- Rising 1–2% per year in adults under 50
Risk Factors
Early Warning Signs (Often Silent!)
Never assume rectal bleeding is “just hemorrhoids” — get it checked immediately.
2025 Screening Guidelines
| Age | Recommendation |
|---|---|
| 45–75 | Screen regularly |
| 76–85 | Discuss with doctor |
| High risk | Start at 40 or earlier |
Best tests: Colonoscopy (gold standard) • FIT (yearly) • Cologuard (every 3 yrs) • Blood test (Shield) • Virtual colonoscopy
Stages & 5-Year Survival
| Stage | Description | Survival |
|---|---|---|
| 0–I | Local | >90% |
| II | Through bowel wall | 70–85% |
| III | Lymph nodes | 50–70% |
| IV | Metastasized | ~15% |
Latest 2025 Treatments
- Surgery (polypectomy, colectomy)
- Chemotherapy (FOLFOX, CAPEOX)
- Targeted therapy (anti-EGFR, anti-VEGF)
- Immunotherapy (pembrolizumab/nivolumab for MSI-H tumors)
- Liver-directed therapies for metastases
- Clinical trials (CAR-T, vaccines)
Prevention (Up to 60% of Cases Avoidable)
- Screen at 45
- High-fiber, plant-heavy diet
- Exercise 150+ min/week
- Limit red/processed meat
- No smoking, moderate alcohol
- Maintain healthy weight
FAQ
Q: When should I start screening?
A: Age 45 for average risk; earlier with family history.
Q: Can young people get it?
A: Yes — rates are rising fastest under age 50.
Q: Is it hereditary?
A: Only 5–10% are strongly hereditary (Lynch/FAP), but family history matters.
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